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SJB3-019A
🥰Excellent
Catalog No. T12926Cas No. 2070015-29-9
SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043, with IC50 of 0.0781 μM. SJB3-019A inhibits cell proliferation and causes cell apoptosis.
SJB3-019A
🥰Excellent
Purity: 99.75%
Catalog No. T12926Cas No. 2070015-29-9
SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043, with IC50 of 0.0781 μM. SJB3-019A inhibits cell proliferation and causes cell apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $95 | In Stock | |
| 2 mg | $139 | In Stock | |
| 5 mg | $235 | In Stock | |
| 10 mg | $357 | In Stock | |
| 25 mg | $590 | In Stock | |
| 50 mg | $852 | In Stock | |
| 100 mg | $1,180 | In Stock | |
| 500 mg | $2,350 | In Stock |
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Purity:99.75%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043, with IC50 of 0.0781 μM. SJB3-019A inhibits cell proliferation and causes cell apoptosis. |
| Targets&IC50 | ID1:78.1 nM , ID1:78.1 nM |
| In vitro | SJB3-019A with IC50 of 0.0781 μM is 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. SJB3-019A increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity. |
| Molecular Weight | 276.25 |
| Formula | C16H8N2O3 |
| Cas No. | 2070015-29-9 |
| Smiles | O=C1c2nc(oc2C(=O)c2ccccc12)-c1cccnc1 |
| Relative Density. | 1.426 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 1 mg/ml, Sonication is recommended.  |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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