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6-Thioguanine

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Catalog No. T3089Cas No. 154-42-7
Alias Thioguanine, 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurine

6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

6-Thioguanine

6-Thioguanine

🥰Excellent
Purity: 100%
Catalog No. T3089Alias Thioguanine, 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurineCas No. 154-42-7
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Pack SizePriceAvailabilityQuantity
50 mg$40In Stock
100 mg$48In Stock
500 mg$72In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Targets&IC50
USP2:40 μM, Plpro:25 μM
In vitro
6-Thioguanine selectively kills BRCA2-deficient tumors in xenograft models as effectively as PARP inhibitors. It eradicates cells and tumors that have developed resistance to PARP inhibitors or cisplatin through genetic reversal via the BRCA2 gene. Additionally, 6-Thioguanine is effective in eliminating PARP inhibitor-resistant tumors with BRCA1 deficiencies.
In vivo
6-Thioguanine is integrated into DNA, differing from typical DNA bases as it serves as a potent UVA chromophore with a peak absorbance at 342 nm. Its incorporation alters topoisomerase II-induced DNA cleavage both in the presence and absence of etoposide. Additionally, 6-Thioguanine induces similar apoptotic responses in mismatch repair-proficient and -deficient HCT116 and HeLa cells.
AliasThioguanine, 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurine
Chemical Properties
Molecular Weight167.19
FormulaC5H5N5S
Cas No.154-42-7
SmilesNC1=NC2=C(N=CN2)C(S)=N1
Relative Density.2.08 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (299.06 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.9812 mL29.9061 mL59.8122 mL299.0609 mL
5 mM1.1962 mL5.9812 mL11.9624 mL59.8122 mL
10 mM0.5981 mL2.9906 mL5.9812 mL29.9061 mL
20 mM0.2991 mL1.4953 mL2.9906 mL14.9530 mL
50 mM0.1196 mL0.5981 mL1.1962 mL5.9812 mL
100 mM0.0598 mL0.2991 mL0.5981 mL2.9906 mL

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