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6-Thioguanine
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Catalog No. T3089Cas No. 154-42-7
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6-Thioguanine
Catalog No. T3089Cas No. 154-42-7
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $40 | In Stock | |
| 100 mg | $48 | In Stock | |
| 500 mg | $72 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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CitedProduct Introduction
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Chemical Properties
Storage & Solubility Information
| Description | 6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. |
| Targets&IC50 | Plpro:25 μM, USP2:40 μM |
| In vitro | 6-Thioguanine selectively kills BRCA2-deficient tumors in xenograft models as effectively as PARP inhibitors. It eradicates cells and tumors that have developed resistance to PARP inhibitors or cisplatin through genetic reversal via the BRCA2 gene. Additionally, 6-Thioguanine is effective in eliminating PARP inhibitor-resistant tumors with BRCA1 deficiencies. |
| In vivo | 6-Thioguanine is integrated into DNA, differing from typical DNA bases as it serves as a potent UVA chromophore with a peak absorbance at 342 nm. Its incorporation alters topoisomerase II-induced DNA cleavage both in the presence and absence of etoposide. Additionally, 6-Thioguanine induces similar apoptotic responses in mismatch repair-proficient and -deficient HCT116 and HeLa cells. |
| Alias | 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurine, Thioguanine |
| Molecular Weight | 167.19 |
| Formula | C5H5N5S |
| Cas No. | 154-42-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (299.06 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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