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IMP-1710
IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]
Catalog No. T37591Cas No. 2383117-96-0
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Purity:99.77%
ee:100%
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IMP-1710
Catalog No. T37591Cas No. 2383117-96-0
IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $298 | In Stock | |
| 5 mg | $729 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,530 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,780 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1] |
| Targets&IC50 | UCHL1:38 nM (fluorescence polarization assay) |
| In vitro | METHODS: Unbiased quantitative chemical proteome analysis (Figure 22a) was used in HEK293 cells treated with IMP-1710 (2, 20 or 200 nM) or vehicle (DMSO) for 10, 60 or 180 minutes to determine the overall proteome. Selectivity. RESULTS IMP-1710 significantly enriched ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) and fibroblast growth factor receptor 2 (FGFR2) at 20 nM. [1] |
| Molecular Weight | 381.43 |
| Formula | C23H19N5O |
| Cas No. | 2383117-96-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: ＜1 mg/mL  DMSO: 20 mg/mL（52.43 mM), Sonication is recommended. Ethanol: 4.5 mg/mL (11.8 mM) Chloroform: 9.0 mg/mL (23.6 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/Chloroform/DMSO
Chloroform/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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