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USP15-IN-1

Catalog No. T61575 CAS 2260826-16-0

USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM). USP15-IN-1 showed high antiproliferative activity against non-small cell lung cancer and leukemia cells. USP15 is an interacting protein of cGAS, and USP15 can promote cGAS to recognize DNA and activate downstream signaling pathways.

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USP15-IN-1, CAS 2260826-16-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM). USP15-IN-1 showed high antiproliferative activity against non-small cell lung cancer and leukemia cells. USP15 is an interacting protein of cGAS, and USP15 can promote cGAS to recognize DNA and activate downstream signaling pathways.
Targets&IC50	USP15:3.76 μM
In vitro	USP15-IN-1 (0.001-5 μM; 48 h) demonstrates significant inhibitory effects on the proliferation of non-small cell lung carcinoma and leukemia cells, as reported in.[1]

Molecular Weight	377.44
Formula	C22H23N3O3
CAS No.	2260826-16-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 90.0 mg/mL (238.4 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chen Yihua, et al. The tetrahydro-beta-carboline micromolecular organic compound and its derivative and medical usage of a kind of hydroxyl substitution. CN108727370A

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

USP15-IN-1 2260826-16-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.