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Brontictuzumab
🥰Excellent
Catalog No. T76785Cas No. 1447814-75-6
Alias OMP52M5, OMP 52M5, Anti-Human NOTCH1 Recombinant Antibody
Brontictuzumab (OMP 52M5) is a monoclonal antibody that targets Notch1 and inhibits activation of the pathway. It has antitumor activity, inhibits tumor cell proliferation, and can be used in the study of leukemias and lymphomas.
Brontictuzumab
Brontictuzumab
🥰Excellent
Catalog No. T76785Alias OMP52M5, OMP 52M5, Anti-Human NOTCH1 Recombinant AntibodyCas No. 1447814-75-6
Brontictuzumab (OMP 52M5) is a monoclonal antibody that targets Notch1 and inhibits activation of the pathway. It has antitumor activity, inhibits tumor cell proliferation, and can be used in the study of leukemias and lymphomas.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $297 | In Stock | |
| 5 mg | $775 | In Stock | |
| 10 mg | $1,230 | In Stock | |
| 25 mg | $1,830 | In Stock | |
| 50 mg | $2,480 | In Stock | |
| 100 mg | $3,330 | In Stock |
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DAPT Cited
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CitedSelect Batch
Concentration:8.63 mg/mL
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Brontictuzumab (OMP 52M5) is a monoclonal antibody that targets Notch1 and inhibits activation of the pathway. It has antitumor activity, inhibits tumor cell proliferation, and can be used in the study of leukemias and lymphomas. |
| In vitro | 0-100 μg/mL Brontictuzumab effectively inhibited the activity of Notch1 signaling pathways, including DLL4 and JAG1/2. In HPB-ALL cell line, treatment with 25 μg/mL Brontictuzumab for 4 days significantly reduced the level of Notch1 intracellular structural domain. [1] In MCL cells, treatment with 25 μg/mL Brontictuzumab for 48 hours inhibited DLL4-mediated overexpression of cleaved Notch1. In addition, the increased phosphorylation of MEK and ERK in Mino cells caused by DLL4 stimulation was effectively blocked. [2] |
| In vivo | In the MCL model, 20 mg/kg Brontictuzumab intraperitoneal injection, administered every 4 days, inhibited DLL4-induced Notch1 activation. [2] Intraperitoneal injection of 15 mg/kg Brontictuzumab significantly reduced tumor burden in a T-ALL xenograft model. [3] |
| Alias | OMP52M5, OMP 52M5, Anti-Human NOTCH1 Recombinant Antibody |
| Cas No. | 1447814-75-6 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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