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Brontictuzumab (OMP 52M5) is a monoclonal antibody that targets Notch1 and inhibits activation of the pathway. It has antitumor activity, inhibits tumor cell proliferation, and can be used in the study of leukemias and lymphomas.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $297 | In Stock | |
5 mg | $775 | In Stock | |
10 mg | $1,230 | In Stock | |
25 mg | $1,830 | In Stock | |
50 mg | $2,480 | In Stock | |
100 mg | $3,330 | In Stock |
Description | Brontictuzumab (OMP 52M5) is a monoclonal antibody that targets Notch1 and inhibits activation of the pathway. It has antitumor activity, inhibits tumor cell proliferation, and can be used in the study of leukemias and lymphomas. |
In vitro | 0-100 μg/mL Brontictuzumab effectively inhibited the activity of Notch1 signaling pathways, including DLL4 and JAG1/2. In HPB-ALL cell line, treatment with 25 μg/mL Brontictuzumab for 4 days significantly reduced the level of Notch1 intracellular structural domain. [1] In MCL cells, treatment with 25 μg/mL Brontictuzumab for 48 hours inhibited DLL4-mediated overexpression of cleaved Notch1. In addition, the increased phosphorylation of MEK and ERK in Mino cells caused by DLL4 stimulation was effectively blocked. [2] |
In vivo | In the MCL model, 20 mg/kg Brontictuzumab intraperitoneal injection, administered every 4 days, inhibited DLL4-induced Notch1 activation. [2] Intraperitoneal injection of 15 mg/kg Brontictuzumab significantly reduced tumor burden in a T-ALL xenograft model. [3] |
Alias | OMP52M5, OMP 52M5, Anti-Human NOTCH1 Recombinant Antibody |
Cas No. | 1447814-75-6 |
Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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