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FLI-06
🥰Excellent
Catalog No. T3075Cas No. 313967-18-9
Alias FLI 06
FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
FLI-06
🥰Excellent
Purity: 100%
Catalog No. T3075Alias FLI 06Cas No. 313967-18-9
FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 2 mg | $44 | In Stock | |
| 5 mg | $68 | In Stock | |
| 10 mg | $101 | In Stock | |
| 25 mg | $181 | In Stock | |
| 50 mg | $328 | In Stock | |
| 100 mg | $571 | In Stock | |
| 500 mg | $1,250 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $75 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM). |
| Targets&IC50 | Notch:2.3 μM(EC50) |
| In vitro | In zebrafish embryos, FLI-06 at a concentration of 50µM inhibits the endogenous Notch signaling pathway. |
| In vivo | In kidney epithelial 293 cells, stable transfection of mutant APP results in significant amyloid deposition. FLI-06 alters the maturation pattern of the APP, subsequently terminating the release of APPs. Furthermore, in Hela cells overexpressing Notch green fluorescent protein, FLI-06 inhibits Notch transport and progression. FLI-06 disrupts the Golgi apparatus and inhibits the secretion of pre-transport proteins in the endoplasmic reticulum during the tubular to sheet-like morphology transition. |
| Kinase Assay | EC50 values of the test compounds are calculated from serial dilution series ranging from 200 to 0.1 μM. Cells are seeded in 96-well plates at a density of 5,000 cells per well in 100 μL medium. The next day, 100 μL medium containing each test compound is added. Cells are incubated for 16 h, fixed and processed for automated microscopy. EC50 estimates are calculated using four-parameter log-logistic fit with the package drc[1]. |
| Alias | FLI 06 |
| Molecular Weight | 438.52 |
| Formula | C25H30N2O5 |
| Cas No. | 313967-18-9 |
| Smiles | CC1=C(C(C2=C(CC(C)(C)CC2=O)N1)c1ccc(cc1)[N+]([O-])=O)C(=O)OC1CCCCC1 |
| Relative Density. | 1.25 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 8.8 mg/mL (20 mM) DMSO: 60 mg/mL (136.82 mM)  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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