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Neural Regeneration Compound Library

Catalog No. L7700
  Library Compound List   Excel SDF

It is well known that neurological diseases that affect the brain or other components of the central nervous system are among the most devastating and complex conditions plaguing mankind today. For thousands of years, damage to the adult central nervous system (CNS) in humans has been regarded as an ‘ailment which cannot be treated’. In the adult mammalian CNS, most injured axons do not regenerate, reflecting a major hurdle for functional recovery after trauma. Numerous efforts over more than a century have been devoted to uncover the underlying mechanisms of regeneration failure. The discovery of neural and glial precursor cells in the adult brain and their ability to grow after injury trumped this assumption. However, in most cases, only small numbers of injured CNS axons can regenerate, consistent with the idea that lack of regeneration in the adult CNS is an intrinsic property of the injured neurons. Therefore, a major challenge has been to define the underlying cellular and molecular mechanisms that determine neuronal intrinsic regenerative ability, with the goal to construct a foundation for designing therapeutic neural repair strategies.

Many signaling pathways (including Ras homolog gene/Rho-associated coiled coil-forming protein kinase (Rho-ROCK), Notch, MAPK, Wnt/β-catenin, mTOR, and ephephrin) participate in and affect repair or regeneration of neurons and axons in the central nervous system. The cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) and Rho-ROCK signaling pathways are key signal transduction pathways for regulating neural and axonal regeneration.

TargetMol collects 529 compounds related to neuroregeneration as Neuroregeneration Compound Library, which can be used for screening of drugs that promote axonal growth and regeneration.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
  • Targets several signaling pathways, such as Notch, MAPK, Wnt/β-catenin, mTOR, etc.;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • tructurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L7700)

Library Composition

PI3K (132)
mTOR (65)
Akt (56)
p38 MAPK (55)
Wnt/beta-catenin (52)
ERK (35)
DNA-PK (27)
MAPK (24)
ATM/ATR (23)
ROCK (22)
JNK (18)
Gamma-secretase (13)
NF-κB (13)
Rho (12)
PKA (9)
CDK (9)
Autophagy (9)
PKC (9)
Src (9)
S6 Kinase (8)
MEK (7)
Apoptosis (7)
AMPK (6)
PPAR (6)
VEGFR (6)
Caspase (6)
Bcr-Abl (5)
Raf (5)
STAT (4)
COX (4)
GSK-3 (4)
TGF-beta/Smad (4)
Aurora Kinase (4)
ASK (4)
PDGFR (4)
Ephrin Receptor (4)
IL Receptor (4)
HDAC (3)
FLT (3)
Glucokinase (3)
GABA Receptor (3)
Endogenous Metabolite (3)
Serine Protease (3)
Epigenetic Reader Domain (3)
DNA/RNA Synthesis (3)
c-Kit (3)
Antiviral (3)
Casein Kinase (3)
Carbonic Anhydrase (3)
TNF (3)
BCL (2)
PDK (2)
PERK (2)
Tyrosine Kinases (2)
Trk receptor (2)
ALK (2)
Antibacterial (2)
Antioxidant (2)
Porcupine (2)
PLK (2)
Beta Amyloid (2)
c-Fms (2)
c-Met/HGFR (2)
S1P Receptor (2)
Sodium Channel (2)
GRK (2)
SGK (2)
EGFR (2)
PARP (2)
Serine/threonin kinase (1)
Tie-2 (1)
PI4K (1)
Ras (1)
transporter (1)
P-gp (1)
5-HT Receptor (1)
PDE (1)
GPR (1)
ACK (1)
Adrenergic Receptor (1)
AhR (1)
Antifection (1)
Arginase (1)
Aromatase (1)
BACE (1)
BTK (1)
DHFR (1)
DNA (1)
DNA Alkylation (1)
Estrogen/progestogen Receptor (1)
FGFR (1)
Hck (1)
Parasite (1)
HCV Protease (1)
AChR (1)
HSV (1)
IGF-1R (1)
Immunology & Inflammation related (1)
Integrin (1)
IκB/IKK (1)
JAK (1)
Lipoxygenase (1)
LRRK2 (1)
MMP (1)
Nrf2 (1)
P450 (1)
HIV Protease (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE