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Pack Size | Price | Availability | Quantity |
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50 mg | Inquiry | Backorder | |
100 mg | Inquiry | Backorder |
Description | Angiotensin 1-7 (Ang-(1-7)) acetate, an endogenous heptapeptide from the renin-angiotensin system (RAS), exhibits cardioprotective effects through anti-inflammatory and anti-fibrotic activities in cardiac cells. It inhibits purified canine ACE activity (IC50 = 0.65 μM) and modulates kinin-induced vasodilation by hindering ACE and facilitating nitric oxide release. This compound also prevents Ang II-induced proliferation and hypertrophy in smooth muscle cells and demonstrates antiangiogenic and growth-inhibitory effects on the endothelium [1] [2] [3]. |
In vitro | Angiotensin 1-7 (Ang-(1-7)) opposes angiotensin II by inhibiting growth in cultured vascular smooth muscle cells, in contrast to angiotensin II's growth-stimulating effect at equal molar concentrations[2], counteracts the myofibroblast phenotype induced by methylglyoxal-modified albumin (MGA) in NRK-52E cells by mitigating prolonged TGF-β-ERK pathway activation[4], and operates through the Mas receptor (MasR), diverging from the angiotensin II/angiotensin II type 1 receptor (AT1R) pathway, facilitating anti-inflammatory, vasodilatory, and neuroprotective actions[5]. |
In vivo | Daily administration of Angiotensin 1-7 (Ang-(1-7)) at doses ranging from 0.01 to 0.06 mg/kg significantly alleviates Di-nitrochlorobenzene (DSS)-induced colitis. This treatment notably decreases the colitis-associated phosphorylation of p38, ERK1/2, and Akt[3]. |
Molecular Weight | 959.06 |
Formula | C43H66N12O13 |
Cas No. | 2855063-75-9 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 125 mg/mL (130.34 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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