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Angiotensin (1-7) acetate
🥰Excellent
Catalog No. T37495Cas No. 2855063-75-9
Alias TXA127 acetate, Talfirastide acetate, Ang-(1-7) acetate
Angiotensin (1-7) acetate (Ang-(1-7) acetate) is an amino acid sequence present in angiotensin, which has antifibrotic and cardioprotective effects and inhibits the activity of purified canine angiotensin converting enzyme (ACE). Angiotensin (1-7) acetate inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer, blocks angiotensin II-induced smooth muscle cell proliferation and hypertrophy, and can be used to study atherosclerosis and novel coronavirus infection.
Angiotensin (1-7) acetate
🥰Excellent
Catalog No. T37495Alias TXA127 acetate, Talfirastide acetate, Ang-(1-7) acetateCas No. 2855063-75-9
Angiotensin (1-7) acetate (Ang-(1-7) acetate) is an amino acid sequence present in angiotensin, which has antifibrotic and cardioprotective effects and inhibits the activity of purified canine angiotensin converting enzyme (ACE). Angiotensin (1-7) acetate inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer, blocks angiotensin II-induced smooth muscle cell proliferation and hypertrophy, and can be used to study atherosclerosis and novel coronavirus infection.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $48 | In Stock | |
| 10 mg | $78 | In Stock | |
| 25 mg | $118 | In Stock | |
| 50 mg | $198 | In Stock | |
| 100 mg | $297 | In Stock | |
| 500 mg | $738 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Angiotensin (1-7) acetate (Ang-(1-7) acetate) is an amino acid sequence present in angiotensin, which has antifibrotic and cardioprotective effects and inhibits the activity of purified canine angiotensin converting enzyme (ACE). Angiotensin (1-7) acetate inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer, blocks angiotensin II-induced smooth muscle cell proliferation and hypertrophy, and can be used to study atherosclerosis and novel coronavirus infection. |
| Targets&IC50 | ACE:0.65 μM |
| In vitro | Pretreatment with Angiotensin (1-7) acetate (2 μM) significantly inhibited the degradation of 125I-[Tyr0]-BK as well as the appearance of BK-(1-7) and BK-(1-5) metabolites in the coronary vascular ring; Angiotensin (1-7) acetate inhibited the angiotensin-converting enzyme activity of purified canine angiotensin converting enzyme with an IC50 of 0.65 μM.[2] |
| In vivo | METHODS: Angiotensin (1-7) acetate (0.01-0.06 mg/kg,daily) was used to treat DSS-induced colitis mice, and colonic expression/activity profiles of ACE2, Ang 1-7, MAS1-Receptor (MAS1-R), MAPK family and Akt were determined by western blotting and immunofluorescence. RESULTS: Enhanced colonic expression of ACE2, Ang 1-7, and MAS1-R was observed in mice after Angiotensin (1-7) acetate treatment and significantly ameliorated DSS-induced colitis. [3] |
| Alias | TXA127 acetate, Talfirastide acetate, Ang-(1-7) acetate |
| Molecular Weight | 959.06 |
| Formula | C43H66N12O13 |
| Cas No. | 2855063-75-9 |
| Smiles | C(C)(O)=O.C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(=N)N)=O)[C@H](C)C)=O)=O)[C@H](CC)C)=O)(=O)N3[C@H](C(O)=O)CCC3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | store at -20°C | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL（52.13 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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