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Losartan potassium

🥰Excellent
Catalog No. T0215Cas No. 124750-99-8
Alias MK 954, DuP-753 potassium, DuP 753

Losartan potassium (DuP-753 potassium), an Angiotensin II Receptor Blocker, selectively and competitively inhibits the binding of angiotensin II to the angiotensin I (AT1) receptor.

Losartan potassium

Losartan potassium

🥰Excellent
Purity: 100%
Catalog No. T0215Alias MK 954, DuP-753 potassium, DuP 753Cas No. 124750-99-8
Losartan potassium (DuP-753 potassium), an Angiotensin II Receptor Blocker, selectively and competitively inhibits the binding of angiotensin II to the angiotensin I (AT1) receptor.
Pack SizePriceAvailabilityQuantity
500 mg$33In Stock
1 g$45In Stock
5 g$107In Stock
10 g$156In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Losartan potassium (DuP-753 potassium), an Angiotensin II Receptor Blocker, selectively and competitively inhibits the binding of angiotensin II to the angiotensin I (AT1) receptor.
Targets&IC50
AT1 receptor:20 nM
In vitro
Losartan competes with the binding of angiotensin II to AT1 receptors, with an IC50 of 20 nM[1]. At 40 μM, losartan affects ISC and prevents the effect of ANGII on ISC[2]. It significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells, and in combination with anti-miR-155, it exhibits a significantly greater antiproliferative effect compared to each drug alone[3].
Cell Research
An MTT assay is used to measure cell proliferation and viability. For the assay, 5000 cells in 200?μL media per well are seeded in a 96 well plate. After overnight incubation to allow for cell attachment, the medium is removed by suction. MTT at 1?mg/mL concentration in serum-free medium is added and then incubated for 4?h at 37°C. After removal of MTT solution, 100?μL of DMSO is added to dissolve formazan crystals. Absorbance at 570?nm and at 600?nm as a reference is then measured using a microplate reader. The difference in absorbance is thus relative to the extent of cell survival.
AliasMK 954, DuP-753 potassium, DuP 753
Chemical Properties
Molecular Weight461.01
FormulaC22H22ClKN6O
Cas No.124750-99-8
Smiles[K+].CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[n-]1
Relative Density.0.986?g/mL?at 25?°C(lit.)
Storage & Solubility Information
Storagestore under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 46.1 mg/mL (100 mM)
DMSO: 55 mg/mL (119.3 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.1692 mL10.8458 mL21.6915 mL108.4575 mL
5 mM0.4338 mL2.1692 mL4.3383 mL21.6915 mL
10 mM0.2169 mL1.0846 mL2.1692 mL10.8458 mL
20 mM0.1085 mL0.5423 mL1.0846 mL5.4229 mL
50 mM0.0434 mL0.2169 mL0.4338 mL2.1692 mL
100 mM0.0217 mL0.1085 mL0.2169 mL1.0846 mL

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