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TK216

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Purity:98.45%

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COA HNMR HPLC

TK216

Catalog No. T13166Cas No. 1903783-48-1

TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.

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Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$89	In Stock
10 mg	$155	In Stock
25 mg	$313	In Stock
50 mg	$538	In Stock
100 mg	$778	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Product Introduction

Bioactivity

Description	TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.
In vitro	In DLBCL cell lines, TK216 (500 nM; for 24-72 hours) induces apoptosis [1]. TK216 (0.03, 0.06, 0.125, 0.25, 0.5 μM) results in a dose-dependent inhibition of proliferation in Ewing Sarcoma A4573 cell line[1]. In DLBCL cell lines,TK216 (0.1, 0.3, 1 μM) induces apoptosis , with the amount of cleaved-Caspase 3 normalized to b-actin and presented as fold over control[1]. TK216 has IC50s of 0.363 μM and 0.152 μM for HL-60 AML cell line and TMD-8 DLBCL cell line[1]. TK216 inhibits EWS-FLI1 (Ewing sarcoma breakpoint region 1/Friend leukemia virus integration 1 fusion protein) protein interactions, leading to a decrease in transcription and proliferation[1].
In vivo	In the TMD-8 xenograft model, TK216 (po; 100 mg/kg; twice daily for 13 days) results in tumor growth inhibition [1].

Chemical Properties

Molecular Weight	376.23
Formula	C19H15Cl2NO3
Cas No.	1903783-48-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 249 mg/mL(661.83 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6579 mL	13.2897 mL	26.5795 mL	132.8974 mL
5 mM	0.5316 mL	2.6579 mL	5.3159 mL	26.5795 mL
10 mM	0.2658 mL	1.3290 mL	2.6579 mL	13.2897 mL
20 mM	0.1329 mL	0.6645 mL	1.3290 mL	6.6449 mL
50 mM	0.0532 mL	0.2658 mL	0.5316 mL	2.6579 mL
100 mM	0.0266 mL	0.1329 mL	0.2658 mL	1.3290 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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