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CXJ-2
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Catalog No. T74782Cas No. 2919976-92-2
CXJ-2, a cyclic peptide, demonstrates moderate affinity for elastin-derived peptides (EDPs) and exhibits potent inhibition of the PI3K/ERK pathway, alongside significant reduction in hepatic stellate cell proliferation and migration, conferring strong antifibrotic efficacy [1].
CXJ-2
CXJ-2
😃Good
Catalog No. T74782Cas No. 2919976-92-2
CXJ-2, a cyclic peptide, demonstrates moderate affinity for elastin-derived peptides (EDPs) and exhibits potent inhibition of the PI3K/ERK pathway, alongside significant reduction in hepatic stellate cell proliferation and migration, conferring strong antifibrotic efficacy [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CXJ-2, a cyclic peptide, demonstrates moderate affinity for elastin-derived peptides (EDPs) and exhibits potent inhibition of the PI3K/ERK pathway, alongside significant reduction in hepatic stellate cell proliferation and migration, conferring strong antifibrotic efficacy [1]. |
| In vitro | CXJ-2, at a concentration of 10 μM incubated for 24 hours, demonstrated dose-dependent inhibition of α-SMA expression in LX2 cells [1]. Additionally, CXJ-2 showed significant activity in suppressing the proliferation of LX2 cells under the same conditions [1]. |
| In vivo | CXJ-2, administered intraperitoneally at a dosage of 150 μg/kg daily for three weeks, significantly alleviates liver fibrosis in mice [1]. Additionally, a single subcutaneous injection of CXJ-2 at 0.1 mg/kg exhibits favorable pharmacokinetic properties [1]. |
| Molecular Weight | 1310.37 |
| Formula | C55H87N15O22 |
| Cas No. | 2919976-92-2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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