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NSC 12
🥰Excellent
Catalog No. T36292Cas No. 102586-30-1
Alias NSC12
NSC 12 is an orally active pan-FGF trap that inhibits FGF-dependent tumor cell proliferation, angiogenesis, and metastasis.NSC 12 binds FGF2 and interferes with its interaction with FGFR1, but does not affect the ability of FGF2 to bind heparin or heparan sulfate proteoglycans (HSPGs), with potential antitumor activity.NSC 12 also organizes several other FGF isoforms to form the HSPG/FGF/FGFR ternary complex.
NSC 12
🥰Excellent
Catalog No. T36292Alias NSC12Cas No. 102586-30-1
NSC 12 is an orally active pan-FGF trap that inhibits FGF-dependent tumor cell proliferation, angiogenesis, and metastasis.NSC 12 binds FGF2 and interferes with its interaction with FGFR1, but does not affect the ability of FGF2 to bind heparin or heparan sulfate proteoglycans (HSPGs), with potential antitumor activity.NSC 12 also organizes several other FGF isoforms to form the HSPG/FGF/FGFR ternary complex.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $112 | In Stock | |
| 10 mg | $188 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NSC 12 is an orally active pan-FGF trap that inhibits FGF-dependent tumor cell proliferation, angiogenesis, and metastasis.NSC 12 binds FGF2 and interferes with its interaction with FGFR1, but does not affect the ability of FGF2 to bind heparin or heparan sulfate proteoglycans (HSPGs), with potential antitumor activity.NSC 12 also organizes several other FGF isoforms to form the HSPG/FGF/FGFR ternary complex. |
| Alias | NSC12 |
| Molecular Weight | 484.52 |
| Formula | C24H34F6O3 |
| Cas No. | 102586-30-1 |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@H](CC(C(F)(F)F)(C(F)(F)F)O)O)[H])[H] |
| Relative Density. | 1.31 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/mL (0.68 mM), < 0.1 mg/mL (insoluble) DMSO: 8 mg/mL (16.51 mM), Sonication is recommended. Ethanol: 8 mg/mL (16.51 mM), Sonication is recommended. DMF: 8 mg/mL (16.51 mM), Sonication is recommended. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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