Shopping Cart

Remove All

Your shopping cart is currently empty

Gedunin

Select Batch

Purity:99.68%

Resource Download

COA HPLC HNMR

Gedunin

Catalog No. T21883Cas No. 2753-30-2

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$413	In Stock
5 mg	$1,230	In Stock
10 mg	$1,680	In Stock
25 mg	$2,490	In Stock
50 mg	$3,360	In Stock
100 mg	$4,530	In Stock
1 mL x 10 mM (in DMSO)	$1,350	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Gedunin"

Product Introduction

Bioactivity

Description

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.

In vitro

Gedunin treatment is highly effective in inducing death of pancreatic cancer cells via intrinsic and extrinsic mediated apoptosis.?Gedunin inhibited metastasis of pancreatic cancer cells by decreasing their EMT, invasive, migratory and colony formation capabilities.?Gedunin treatment also inhibited sonic hedgehog signaling pathways.?Further, experiments with recombinant sonic hedgehog protein and Gli inhibitor (Gant-61) demonstrated that gedunin induces its anti-metastatic effect through inhibition of sonic hedgehog signaling.?The anti-cancer effect of gedunin was further validated using xenograft mouse model.

Chemical Properties

Molecular Weight	482.57
Formula	C28H34O7
Cas No.	2753-30-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (124.33 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0722 mL	10.3612 mL	20.7224 mL	103.6119 mL
5 mM	0.4144 mL	2.0722 mL	4.1445 mL	20.7224 mL
10 mM	0.2072 mL	1.0361 mL	2.0722 mL	10.3612 mL
20 mM	0.1036 mL	0.5181 mL	1.0361 mL	5.1806 mL
50 mM	0.0414 mL	0.2072 mL	0.4144 mL	2.0722 mL
100 mM	0.0207 mL	0.1036 mL	0.2072 mL	1.0361 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc