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16,16-dimethyl PGA2 is a metabolism-resistant analog of PGA2 with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 μg/ml. Daily infusion of 10 μg of 16,16-dimethyl PGA2 methyl ester into mice infected with influenza A virus increased survival by 40%. Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $333 | 35 days | |
5 mg | $1,430 | 35 days | |
10 mg | $2,590 | 35 days |
Description | 16,16-dimethyl PGA2 is a metabolism-resistant analog of PGA2 with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 μg/ml. Daily infusion of 10 μg of 16,16-dimethyl PGA2 methyl ester into mice infected with influenza A virus increased survival by 40%. Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time. |
Alias | 16,16-dimethyl Prostaglandin A2 |
Molecular Weight | 362.5 |
Formula | C22H34O4 |
Cas No. | 41691-92-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: >50 mg/mL (from PGA1), Sonication is recommended. Ethanol: >100 mg/mL (from PGA1), Sonication is recommended. DMF: >75 mg/mL (from PGA1), Sonication is recommended. PBS (pH 7.2): >2.4 mg/mL (from PGA1), Sonication is recommended. |
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