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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $34 | In Stock | |
5 mg | $55 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $369 | In Stock | |
100 mg | $549 | In Stock | |
500 mg | $1,190 | In Stock | |
1 mL x 10 mM (in DMSO) | $93 | In Stock |
Description | TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. |
In vivo | TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation. |
Alias | CLT-003, 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 |
Molecular Weight | 322.4 |
Formula | C20H22N2O2 |
Cas No. | 100823-03-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (139.57 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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