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TH5427 hydrochloride

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Catalog No. T39785Cas No. 2253744-57-7

TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.

TH5427 hydrochloride
Other Forms of TH5427 hydrochloride:
TH5427T39785L2253744-56-6
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TH5427 hydrochloride

😃Good
Catalog No. T39785Cas No. 2253744-57-7
TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
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10 mg$47835 days
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Product Introduction

Bioactivity
Description
TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
In vitro
TH5427 hydrochloride effectively suppresses progestin-induced nuclear ATP synthesis in breast cancer cells and markedly inhibits both EGFR and MMTV-luc expression post-progestin stimulation. Furthermore, TH5427 hydrochloride nullifies the proliferative response dependent on progestin in T47D WT cells[1].
Chemical Properties
Molecular Weight527.79
FormulaC20H21Cl3N8O3
Cas No.2253744-57-7
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

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