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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $163 | In Stock | |
5 mg | $372 | In Stock | |
10 mg | $538 | In Stock | |
25 mg | $919 | In Stock | |
50 mg | $1,180 | In Stock | |
100 mg | $1,560 | In Stock |
Description | TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM). |
In vitro | In HL-60 cell lysates, TH5427(20?μM) stabilized NUDT5 to nearly the same levels as observed in the 37?°C DMSO control. TH5427 was the most potent stabilizer under the described conditions with an apparent EC50 of 2.1?μM. Accordingly, TH5427 had a positive, dose-dependent shift in the apparent Tagg—the temperature at which 50 % of the target protein denatures and aggregates (TH5427 shifted NUDT5 Tagg up to?≈?8?°C)[1]. |
Molecular Weight | 491.33 |
Formula | C20H20Cl2N8O3 |
Cas No. | 2253744-56-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 3.67 mg/mL (7.46 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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