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TH5427
🥰Excellent
Catalog No. T39785LCas No. 2253744-56-6
TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).
TH5427
🥰Excellent
Purity: 99.54%
Catalog No. T39785LCas No. 2253744-56-6
TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 2 mg | $139 | In Stock | |
| 5 mg | $223 | In Stock | |
| 10 mg | $323 | In Stock | |
| 25 mg | $551 | In Stock | |
| 50 mg | $693 | In Stock | |
| 100 mg | $936 | In Stock | |
| 200 mg | $1,260 | In Stock |
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TH1760
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TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine.
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Purity:99.54%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM). |
| Targets&IC50 | NUDT5:29 nM(MG assay) |
| In vitro | In HL-60 cell lysates, TH5427(20?μM) stabilized NUDT5 to nearly the same levels as observed in the 37?°C DMSO control. TH5427 was the most potent stabilizer under the described conditions with an apparent EC50 of 2.1?μM. Accordingly, TH5427 had a positive, dose-dependent shift in the apparent Tagg—the temperature at which 50 % of the target protein denatures and aggregates (TH5427 shifted NUDT5 Tagg up to?≈?8?°C)[1]. |
| Molecular Weight | 491.33 |
| Formula | C20H20Cl2N8O3 |
| Cas No. | 2253744-56-6 |
| Smiles | C(N1C2=C(N=C1N3CCNCC3)N(C)C(=O)N(C)C2=O)C=4OC(=NN4)C5=CC(Cl)=C(Cl)C=C5 |
| Relative Density. | 1.68 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 3.67 mg/mL (7.46 mM), Sonication is recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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