Shopping Cart
- Remove All
Your shopping cart is currently empty
TH1760
Catalog No. T67864Cas No. 2567914-01-4
Alias MKB
TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine.
TH1760
Catalog No. T67864Alias MKBCas No. 2567914-01-4
TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $50 | In Stock | |
| 10 mg | $90 | In Stock | |
| 25 mg | $210 | In Stock | |
| 50 mg | $398 | In Stock | |
| 100 mg | $592 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "TH1760"
TH5427
T39785L2253744-56-6
TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).
- $98
Size
QTY
Select Batch
Purity:97.03%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine. |
| Targets&IC50 | NUDT15:25 nM |
| In vitro | TH1760 (0-100 µ M) maintained the thermal denaturation of NUDT15 in a dose-dependent manner. TH1760 (0, 5, 10, 20, and 50 µ M) increased the accumulation of thiopurine (6-TG) in a dose-dependent manner. TH1760 (10 µ M) increased the sensitivity of HCT116 and HCT116 3-6 cells to 6-TG. TH1760 has a higher sensitivity to BJ-RAS cells compared to BJ-hTERT cells. TH1760 (10 µ M; 16 h) promotes the accumulation and incorporation of 6-TG in HL-60 cells. TH1760 increased the expression of γ The expression of H2AX, caspase3, Cleared, and cPARP [1]. TH1760 (0.05, 0.17, 0.55, and 1.8 µ M; 4 d) enhanced the anti-leukemia effect of 6-TG in a dose-dependent manner [2]. |
| Alias | MKB |
| Molecular Weight | 426.45 |
| Formula | C20H18N4O5S |
| Cas No. | 2567914-01-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1.8 mg/mL (4.2 mM) | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
| |||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy TH1760 | purchase TH1760 | TH1760 cost | order TH1760 | TH1760 chemical structure | TH1760 in vitro | TH1760 formula | TH1760 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.