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ML334

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Purity:98.06%

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COA HNMR LCMS

ML334

Catalog No. T12078Cas No. 1432500-66-7

ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation.

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Pack Size	Price	Availability	Quantity
1 mg	$49	In Stock

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Product Introduction

Bioactivity

Description	ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation.
In vitro	Treatment of HEK293 cells with ML334 (LH601A; 50-100 μM; 6-16 hours) increases NQO1 and TRX1 mRNA levels by 2 to 3 times at both 6 and 16 hours. Additionally, at 6 hours, ML334 enhances HO-1 mRNA expression by 4 to 7 times, with a relatively smaller change in fold increase observed at 16 hours [2]. ML334 (LH601A; 50-100 μM; 16 hours; HEK293 cells) induces the expression of HO-1 and TRX1 proteins in HEK293 cells [2]. Furthermore, ML334 (LH601A) stimulates the expression and nuclear translocation of NRF2 in HEK293 cells [2].
Alias	LH601A

Chemical Properties

Molecular Weight	446.49
Formula	C26H26N2O5
Cas No.	1432500-66-7

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (67.19 mM)

Ethanol: 30 mg/mL (67.19 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1198 mL

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