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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | cis-4-Br-2,5-F2-PCPA (S1024) inhibits LSD1 and LSD2 with Ki values of 94 nM and 8.4 μM, respectively. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells [1]. |
In vitro | cis-4-Br-2,5-F2-PCPA (compound 7c) effectively suppresses the proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells, with IC50 values of 12 µM for CCRF-CEM and 16 µM for Jurkat lines, while demonstrating no cytotoxic effects on the human normal fibroblast cell line WI-38. Additionally, at a concentration of 20 µM over a 24-hour period, it significantly enhances the level of dimethylated H3K4 (H3K4me2) by 2.9 times compared to the control, indicating its role as a chemical inhibitor of LSD1 and LSD2 enzymes, as evidenced by Western Blot Analysis. |
Molecular Weight | 248.07 |
Formula | C9H8BrF2N |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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