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PY-60
🥰Excellent
Catalog No. T9566Cas No. 2765218-56-0
PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2) (Kd value of 1.4 µM). PY-60 activates a pro-proliferative, YAP-dependent transcriptional program in adult animals that are able to remodel the epidermis through proliferation.
PY-60
🥰Excellent
Purity: 99.32%
Catalog No. T9566Cas No. 2765218-56-0
PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2) (Kd value of 1.4 µM). PY-60 activates a pro-proliferative, YAP-dependent transcriptional program in adult animals that are able to remodel the epidermis through proliferation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $116 | In Stock | |
| 5 mg | $287 | In Stock | |
| 10 mg | $478 | In Stock | |
| 25 mg | $789 | In Stock | |
| 50 mg | $1,080 | In Stock | |
| 100 mg | $1,480 | In Stock | |
| 500 mg | $2,970 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $318 | In Stock |
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Purity:99.32%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2) (Kd value of 1.4 µM). PY-60 activates a pro-proliferative, YAP-dependent transcriptional program in adult animals that are able to remodel the epidermis through proliferation. |
| Targets&IC50 | ANXA2:1.4 µM |
| In vitro | METHODS: PY-60 (20µM, 24 hours) treated 293A cells, and immunoblot analysis of PP2CA-V5 was performed on material obtained by anti-FLAG immunoprecipitation from cells overexpressing ANXA2-FLAG. RESULTS In 293A cells treated with PY-60, the association between ANXA2 and PPP2CA increased significantly. [1] |
| In vivo | METHODS: PY-60 (5 mg/kg, intravenous injection, 24 hours) was administered to mice, and the changes in plasma levels in mice were evaluated and the intrinsic clearance in mice was measured. RESULTS The half-life (T1/2) was 0.46 h, and the AUC0-24 was 623 ng*h/mL. At the same time, PY-60 showed a rapid clearance rate (133 mL/min/kg). [2] |
| Molecular Weight | 313.37 |
| Formula | C16H15N3O2S |
| Cas No. | 2765218-56-0 |
| Smiles | C(NCCCC1=NC=CS1)(=O)C=2C=C(ON2)C3=CC=CC=C3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 95 mg/mL (303.16 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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