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PY-60

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Purity:99.32%

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COA HPLC HNMR

PY-60

Catalog No. T9566Cas No. 2765218-56-0

PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermis through proliferation.

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Pack Size	Price	Availability
1 mg	$116	In Stock
5 mg	$287	In Stock
10 mg	$478	In Stock
25 mg	$789	In Stock
50 mg	$1,080	In Stock
100 mg	$1,480	In Stock
500 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$318	In Stock

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Product Introduction

Bioactivity

Description	PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermis through proliferation.
Targets&IC50	ANXA2:1.4 µM
In vitro	PY-60 robustly increased the levels of YAP-controlled transcripts (that is, ANRKD1, CYR61 and CTGF) in 293A cells and other human cell lines (that is, MCF10A, HEK293T, H69 and HaCaT), but did not augment the levels of YAP itself (YAP1). PY-60 induced luciferase activity in 293A-TEAD-LUC cells in the presence or absence of serum when cells were plated at high cell density with EC50s of 1.5 and 1.6 µM, respectively. PY-60 also promoted the association of YAP and TEAD proteins in cells in a dose-dependent manner and induced the nuclear localization of YAP in response to increased cell density[1].
In vivo	PY-60 (10 uM) promoted a dramatic expansion of keratinocytes and K14-positive precursors. PY-60 resulted in an approximate doubling of epidermal thickness, a result derived from an increased number of keratinocytes per unit length of skin[1].

Chemical Properties

Molecular Weight	313.37
Formula	C16H15N3O2S
Cas No.	2765218-56-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 95 mg/mL (303.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1911 mL	15.9556 mL	31.9112 mL	159.5558 mL
5 mM	0.6382 mL	3.1911 mL	6.3822 mL	31.9112 mL
10 mM	0.3191 mL	1.5956 mL	3.1911 mL	15.9556 mL
20 mM	0.1596 mL	0.7978 mL	1.5956 mL	7.9778 mL
50 mM	0.0638 mL	0.3191 mL	0.6382 mL	3.1911 mL
100 mM	0.0319 mL	0.1596 mL	0.3191 mL	1.5956 mL

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