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AICAR
🥰Excellent
Catalog No. T1477Cas No. 2627-69-2
Alias NSC105823, AICAR (Acadesine), AICA Riboside, Acadesine
AICAR (Acadesine) is an AMPK activator that causes ZMP accumulation, thereby mimicking the stimulatory effect of AMP on both AMPK and AMPKK. It is commonly used in research related to diabetes, cardiovascular diseases, and tumors.
AICAR
🥰Excellent
Purity: 99.71%
Catalog No. T1477Alias NSC105823, AICAR (Acadesine), AICA Riboside, AcadesineCas No. 2627-69-2
AICAR (Acadesine) is an AMPK activator that causes ZMP accumulation, thereby mimicking the stimulatory effect of AMP on both AMPK and AMPKK. It is commonly used in research related to diabetes, cardiovascular diseases, and tumors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $30 | In Stock | |
| 50 mg | $42 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.71%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | AICAR (Acadesine) is an AMPK activator that causes ZMP accumulation, thereby mimicking the stimulatory effect of AMP on both AMPK and AMPKK. It is commonly used in research related to diabetes, cardiovascular diseases, and tumors. |
| In vitro | In rat hepatocytes, Acadesine (500 μM) induced transient activation of MPK, significantly inhibited fatty acid and sterol synthesis, and induced inactivation of HMG-CoA reductase in rat hepatocytes.In B-CLL cells (EC50=380 μM), Acadesine (0.5 mM) induced apoptosis in B-CLL cells and activated AMPK. . |
| In vivo | In rat hepatocytes, Acadesine (500 μM) induced transient activation of MPK, significantly inhibited fatty acid and sterol synthesis, and induced inactivation of HMG-CoA reductase in rat hepatocytes.In B-CLL cells (EC50=380 μM), Acadesine (0.5 mM) induced apoptosis in B-CLL cells and activated AMPK. . |
| Cell Research | Acadesine is added to K562 cell lines or primary cells (103 CD34+ cells/mL) growing in semisolid methyl cellulose medium. MethoCult H4100 or H4236 are used for cell lines and primary CD34+ cells respectively. Colonies are detected after 10 days of culture by adding 1 mg/mL of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reagent and are scored by Image J quantification software. (Only for Reference) |
| Alias | NSC105823, AICAR (Acadesine), AICA Riboside, Acadesine |
| Molecular Weight | 258.23 |
| Formula | C9H14N4O5 |
| Cas No. | 2627-69-2 |
| Smiles | NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N |
| Relative Density. | 2.06 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 19.4 mg/mL (75 mM) DMSO: 80 mg/mL (309.8 mM)  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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