AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.

AICAR monophosphate (Aica ribonucleotide) is a purine precursor with antineoplastic activity and can be used in studies about type 2 diabetes.

AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-inflammatory cytokines and iNOS.

SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).

MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity.

FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.

ATIC-IN-1 (compound 14) acetate is an ATIC dimerization inhibitor with a K i value of 685 nM, essential for AICAR transformylase activity. It demonstrates anti-tumor effects by decreasing cell proliferation and division rates [1].

ATIC-IN-1 (compound 14) serves as an inhibitor specifically aimed at the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), with a K i of 685 nM. This dimerization is essential for the enzyme's aminoimidazole carboxamide ribonucleotide (AICAR) transformylase function. Furthermore, ATIC-IN-1 demonstrates anti-tumor properties by diminishing both cell proliferation and cell division rates [1].

MOTS-c(human) acetate, a mitochondrial-derived peptide, induces the accumulation of AMP analog AICAR, enhances AMPK activation, and upregulates its downstream target, GLUT4. This compound promotes glucose uptake and enhances insulin sensitivity, playing a significant role in managing obesity, diabetes, and supporting exercise and longevity outcomes [1].