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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $1,460 | Backorder |
Description | SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM). |
In vitro | Upon glucose starvation, the concentration of cellular SAICAR oscillates and enhances PKM2 activity in cancer cells, facilitating survival under glucose-limited conditions. This interaction between SAICAR and PKM2 is crucial, as cancer cells with higher levels of SAICAR (such as adsl-kd cells or those overexpressing PAICS) demonstrate improved survival, whereas cells deficient in PAICS (paics-kd cells) exhibit earlier mortality compared to controls (control-kd cells). Furthermore, the SAICAR-PKM2 complex is instrumental in phosphorylating and activating Erk1/2, thereby increasing PKM2's affinity for SAICAR through subsequent phosphorylation. This complex is also essential for continuous Erk1/2 activation and for promoting mitogen-induced cell proliferation, underscoring the importance of the SAICAR-PKM2 interaction in inducing H3 T11 and Erk1/2 phosphorylation, thereby facilitating cancer cell survival and proliferation in environments with limited glucose availability. |
Molecular Weight | 454.28 |
Formula | C13H19N4O12P |
Cas No. | 3031-95-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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