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SAICAR

SAICAR
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SAICAR

Catalog No. T16837Cas No. 3031-95-6
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).
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Product Introduction

Bioactivity
Description
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).
In vitro
Upon glucose starvation, the concentration of cellular SAICAR oscillates and enhances PKM2 activity in cancer cells, facilitating survival under glucose-limited conditions. This interaction between SAICAR and PKM2 is crucial, as cancer cells with higher levels of SAICAR (such as adsl-kd cells or those overexpressing PAICS) demonstrate improved survival, whereas cells deficient in PAICS (paics-kd cells) exhibit earlier mortality compared to controls (control-kd cells). Furthermore, the SAICAR-PKM2 complex is instrumental in phosphorylating and activating Erk1/2, thereby increasing PKM2's affinity for SAICAR through subsequent phosphorylation. This complex is also essential for continuous Erk1/2 activation and for promoting mitogen-induced cell proliferation, underscoring the importance of the SAICAR-PKM2 interaction in inducing H3 T11 and Erk1/2 phosphorylation, thereby facilitating cancer cell survival and proliferation in environments with limited glucose availability.
Chemical Properties
Molecular Weight454.28
FormulaC13H19N4O12P
Cas No.3031-95-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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