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AICAR phosphate

🥰Excellent
Catalog No. T14149Cas No. 681006-28-0
Alias AICA Riboside phosphate, Acadesine phosphate

AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy. It serves as an adenosine analog, regulating glucose and lipid metabolism, and inhibiting the production of pro-inflammatory cytokines and iNOS.

AICAR phosphate

AICAR phosphate

🥰Excellent
Purity: 100%
Catalog No. T14149Alias AICA Riboside phosphate, Acadesine phosphateCas No. 681006-28-0
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy. It serves as an adenosine analog, regulating glucose and lipid metabolism, and inhibiting the production of pro-inflammatory cytokines and iNOS.
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25 mg$189In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy. It serves as an adenosine analog, regulating glucose and lipid metabolism, and inhibiting the production of pro-inflammatory cytokines and iNOS.
In vitro
HepG2 cells were treated with different concentrations of AICAR phosphate (0.1-1.0 mM) for 12, 24, and 48 hours, respectively. The final results demonstrated that AICAR phosphate reduced the expression of the insulin receptor protein[1].
In vivo
Male 5-week-old ZDF rats were either subcutaneously injected with a single dose of AICAR phosphate (0.5 mg/g) or subjected to a single bout of treadmill running. The results showed that compared to untreated control ZDF rats, both the exercise group and the rats receiving AICAR phosphate injection exhibited significantly increased AMPK-α2 activity in the white gastrocnemius muscle[2].
AliasAICA Riboside phosphate, Acadesine phosphate
Chemical Properties
FormulaC9H14N4O5.xH3O4P
Cas No.681006-28-0
SmilesO[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(N)=C(C(N)=O)N=C2.P(=O)(O)(O)O xH3O4P
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 75 mg/mL (210.54 mM)
H2O: 80 mg/mL (224.57 mM), Sonication is recommended.

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