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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $72 | In Stock | |
5 mg | $255 | In Stock | |
10 mg | $416 | In Stock | |
25 mg | $673 | In Stock | |
50 mg | $947 | In Stock | |
1 mL x 10 mM (in DMSO) | $279 | In Stock |
Description | VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins. |
In vitro | VT104 is a pan-TEAD binder, with low nanomolar IC50 values in proliferation assays using YAP1/TEAD-dependent cell lines [1]. |
In vivo | VT104 also exhibits a favorable pharmacokinetics profile with exposure sufficient for daily dosing in mice. In the NCI-H226 xenograft efficacy model, VT-104 is highly active with a TGI = 102% at 3 mg/kg PO [1]. |
Molecular Weight | 420.43 |
Formula | C25H19F3N2O |
Cas No. | 2417718-25-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (71.35 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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