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IK-930

🥰Excellent
Catalog No. T77580Cas No. 2563892-44-2
Alias compound I-32

IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.

IK-930

IK-930

🥰Excellent
Purity: 98.86%
Catalog No. T77580Alias compound I-32Cas No. 2563892-44-2
IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.
Pack SizePriceAvailabilityQuantity
5 mg48 €In Stock
10 mg79 €In Stock
25 mg163 €In Stock
50 mg264 €In Stock
100 mg429 €In Stock
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Purity:98.86%
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Product Introduction

Bioactivity
Description
IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.
Targets&IC50
TEAD:<0.1 µM(EC50)
In vitro
IK-930 (0-1 μM) is a potent and selective TEAD inhibitor.[2]
In vivo
IK-930 (compound I-32) (10 mg/kg; p.o.) demonstrates favorable pharmacokinetic parameters in BALB/c mice, with a Cmax of 1088 ng/mL and an AUC 0-last of 4581 ng·h/mL.[1]
Aliascompound I-32
Chemical Properties
Molecular Weight424.44
FormulaC19H19F3N4O2S
Cas No.2563892-44-2
SmilesN(CC1=CC=C(C(F)(F)F)C=C1)C2=C(C=C(S(NC)(=O)=O)C=C2)C=3N=CN(C)C3
Relative Density.1.36 g/cm3 (Predicted)
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 90.0 mg/mL (212.0 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3560 mL11.7802 mL23.5605 mL117.8023 mL
5 mM0.4712 mL2.3560 mL4.7121 mL23.5605 mL
10 mM0.2356 mL1.1780 mL2.3560 mL11.7802 mL
20 mM0.1178 mL0.5890 mL1.1780 mL5.8901 mL
50 mM0.0471 mL0.2356 mL0.4712 mL2.3560 mL
100 mM0.0236 mL0.1178 mL0.2356 mL1.1780 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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