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VT107
🥰Excellent
Catalog No. T35545Cas No. 2417718-63-7
VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.[1]
VT107
🥰Excellent
Purity: 99.73%
Catalog No. T35545Cas No. 2417718-63-7
VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.[1]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $147 | In Stock | |
| 5 mg | $369 | In Stock | |
| 10 mg | $556 | In Stock | |
| 25 mg | $896 | In Stock | |
| 50 mg | $1,220 | In Stock | |
| 100 mg | $1,650 | In Stock | |
| 500 mg | $3,290 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $397 | In Stock |
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CitedSelect Batch
Purity:99.73%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.[1] |
| In vitro | METHODS: HEK293T cells were treated with 3 μmol/L VT107 for 20 h. After incubation of cells with compounds and alkyne palmitate overnight, the relevant TEAD proteins were immunoprecipitated using specific TEAD antibodies, followed by click chemistry and streptavidin western blot analysis to examine the effects of these compounds on the palmitoylation of endogenous TEAD1, TEAD3, and TEAD4 proteins. RESULTS VT107 effectively blocked the palmitoylation of endogenous TEAD1 and TEAD3 proteins, and also effectively blocked the palmitoylation of endogenous TEAD4 protein. In addition, VT107 showed a strong inhibitory effect on the proliferation of NF2 mutant/deficient cell lines. [1] |
| In vivo | METHODS: VT107 was administered intravenously or orally at a dose of 10 mg/kg. Blood was drawn from the saphenous vein at designated time points. Compounds were quantified by LC/MS-MS using a QTRAP 6500 RESULTS The bioavailability of VT107 was 55%. The half-life after intravenous administration was 2.7 hours. [1] |
| Molecular Weight | 435.44 |
| Formula | C25H20F3N3O |
| Cas No. | 2417718-63-7 |
| Smiles | C[C@H](NC(=O)c1ccc2c(cccc2c1)-c1ccc(cc1)C(F)(F)F)c1cccc(N)n1 |
| Relative Density. | 1.295 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (114.83 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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