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VT103

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Purity:98.73%

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COA HNMR HPLC LCMS

VT103

Catalog No. T62077Cas No. 2290608-13-6

VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEAD auto-palmitoylation, and blocking the interaction between YAP/TAZ and TEAD.VT103 can be used in the study of HER2-positive breast cancer, prostate cancer, and triple-negative breast cancer.

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Pack Size	Price	Availability
1 mg	$132	In Stock
5 mg	$328	In Stock
10 mg	$563	In Stock
25 mg	$1,110	In Stock
50 mg	$1,490	In Stock
100 mg	$1,970	In Stock
500 mg	$3,950	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock

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Product Introduction

Bioactivity

Description	VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEAD auto-palmitoylation, and blocking the interaction between YAP/TAZ and TEAD.VT103 can be used in the study of HER2-positive breast cancer, prostate cancer, and triple-negative breast cancer.
In vitro	VT103 (3 mmol/L; 4 or 24 h; NF2-deficient NCI-H226 cells) selectively disrupts YAP–TEAD1 interaction.[1] VT103 (3 μM; HEK293T cells) appeared to be TEAD1-selective, as it does not block palmitoylation of TEAD2, TEAD3, or TEAD4.[1] VT103 results in the disappearance of palmitoylated TEAD1 with a concomitant increase in unpalmitoylated TEAD1. VT103 shows an IC50 of 1.02 nM in the YAP reporter assay.[1]
In vivo	VT103 (0.3~10 mg/kg; p.o.; once per day; NCI-H226-tumor-bearing mice) blocks tumor growth even at 0.3 mg/kg[1]. Pharmacokinetics of VT103 in mice.[1]
Alias	VT-103, VT 103

Chemical Properties

Molecular Weight	410.41
Formula	C18H17F3N4O2S
Cas No.	2290608-13-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (121.83 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4366 mL	12.1829 mL	24.3659 mL	121.8294 mL
5 mM	0.4873 mL	2.4366 mL	4.8732 mL	24.3659 mL
10 mM	0.2437 mL	1.2183 mL	2.4366 mL	12.1829 mL
20 mM	0.1218 mL	0.6091 mL	1.2183 mL	6.0915 mL
50 mM	0.0487 mL	0.2437 mL	0.4873 mL	2.4366 mL
100 mM	0.0244 mL	0.1218 mL	0.2437 mL	1.2183 mL

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