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Ro 41-5253
🥰Excellent
Catalog No. T28589Cas No. 144092-31-9
Alias Ro-41-5253, Ro 415253
Ro 41-5253 is an orally active RARα antagonist, ligand, and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation, and induces apoptosis in MCF-7 and ZR-75.1 estrogen receptor-positive breast cancer cells.
Ro 41-5253
🥰Excellent
Purity: 98%
Catalog No. T28589Alias Ro-41-5253, Ro 415253Cas No. 144092-31-9
Ro 41-5253 is an orally active RARα antagonist, ligand, and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation, and induces apoptosis in MCF-7 and ZR-75.1 estrogen receptor-positive breast cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock |
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ro 41-5253 is an orally active RARα antagonist, ligand, and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation, and induces apoptosis in MCF-7 and ZR-75.1 estrogen receptor-positive breast cancer cells. |
| Targets&IC50 | RARβ:2.4 μM, RARγ:3.3 μM, RARα:60 nM |
| In vitro | In human breast cancer cell lines MCF-7 and ZR 75.1, Ro 41-5253 (1 nM-10 μM; for 10 days) inhibited cell growth. At a concentration of 10 μM, the inhibition rate of MCF-7 cell growth was 81%, 30% at 1 μM, and no significant inhibition was observed at concentrations below 0.1 μM. For ZR 75.1 cells, the growth inhibition rate was 74% at 10 μM, 63% at 1 μM, and 42% at 0.1 μM[1]. |
| In vivo | In six-week-old athymic female Balb/c mice implanted with MCF-7 cell line, Ro 41-5253 (10, 30, 100, 300, and 600 mg/kg; oral gavage; once weekly; for 4 weeks) resulted in a reduction in tumor volume at doses of 10, 30, and 100 mg/kg, with no toxic side effects[2]. |
| Alias | Ro-41-5253, Ro 415253 |
| Molecular Weight | 484.65 |
| Formula | C28H36O5S |
| Cas No. | 144092-31-9 |
| Smiles | CCCCCCCOc1cc2c(cc1\C(C)=C\c1ccc(cc1)C(O)=O)C(C)(C)CCS2(=O)=O |
| Relative Density. | 1.154g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (165.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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