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TAK-448 acetate
🥰Excellent
Catalog No. TP1093Cas No. 1470374-22-1
Alias TAK-448 acetate (1234319-68-6 Free base), MVT-602 acetate
TAK-448 acetate (MVT-602 acetate) is a synthetic peptide and small molecule KISS1R agonist with antitumor activity. It inhibits the proliferation of VCaP cells and is useful in prostate cancer research.
TAK-448 acetate
🥰Excellent
Purity: 99.88%
Catalog No. TP1093Alias TAK-448 acetate (1234319-68-6 Free base), MVT-602 acetateCas No. 1470374-22-1
TAK-448 acetate (MVT-602 acetate) is a synthetic peptide and small molecule KISS1R agonist with antitumor activity. It inhibits the proliferation of VCaP cells and is useful in prostate cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $648 | In Stock | |
| 50 mg | $912 | In Stock |
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Purity:99.88%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TAK-448 acetate (MVT-602 acetate) is a synthetic peptide and small molecule KISS1R agonist with antitumor activity. It inhibits the proliferation of VCaP cells and is useful in prostate cancer research. |
| Targets&IC50 | KISS1R:632 pM, KISS1R:460 pM |
| In vivo | A single injection of TAK-448 significantly increases plasma levels of follicle-stimulating hormone and testosterone (T) in male rats. In the androgen-sensitive prostate cancer model of male rats with VCaP xenografts, TAK-448 (0.01, 0.03, 0.3, 3 mg/kg; i.h.; 0,28 days) exhibits greater anti-tumor effects[1]. |
| Alias | TAK-448 acetate (1234319-68-6 Free base), MVT-602 acetate |
| Molecular Weight | 1285.41 |
| Formula | C60H84N16O16 |
| Cas No. | 1470374-22-1 |
| Smiles | CC(O)=O.CNC(=N)NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (62.24 mM), Sonication is recommended. H2O: 30 mg/mL (23.34 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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