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FIDAS-5

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Purity:98.3%

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COA HPLC HNMR

FIDAS-5

Catalog No. T11285Cas No. 1391934-98-7

FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities.

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Pack Size	Price	Availability
1 mg	$54	In Stock
2 mg	$77	In Stock
5 mg	$118	In Stock
10 mg	$196	In Stock
25 mg	$349	In Stock
50 mg	$538	In Stock
100 mg	$778	In Stock
500 mg	$1,490	In Stock

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Product Introduction

Bioactivity

Description	FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities.
Targets&IC50	Mat2A:2.1 μM
In vitro	FIDAS-5 induces the expression of cell cycle inhibitor, p21WAF1/CIP1. FIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-5 (3 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells.
In vivo	Mice are treated with FIDAS-5 (20 mg/kg) for 1 week.?The liver SAM levels are significantly reduced.FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight.

Chemical Properties

Molecular Weight	261.72
Formula	C15H13ClFN
Cas No.	1391934-98-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (477.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8209 mL	19.1044 mL	38.2088 mL	191.0439 mL
5 mM	0.7642 mL	3.8209 mL	7.6418 mL	38.2088 mL
10 mM	0.3821 mL	1.9104 mL	3.8209 mL	19.1044 mL
20 mM	0.1910 mL	0.9552 mL	1.9104 mL	9.5522 mL
50 mM	0.0764 mL	0.3821 mL	0.7642 mL	3.8209 mL
100 mM	0.0382 mL	0.1910 mL	0.3821 mL	1.9104 mL

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Keywords

p21WAF1/CIP1S-adenosylmethionineinhibitMAT2Aanti-proliferationSAHInhibitoranti-cancerCyclinD1FIDAS5c-MycSAMFIDAS-5FIDAS 5colorectal