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Angoline

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Purity:97.9%

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COA HNMR HPLC

Angoline

Catalog No. TN6739Cas No. 21080-31-9

Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.

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Pack Size	Price	Availability
1 mg	$60	In Stock
5 mg	$147	In Stock
10 mg	$217	In Stock
25 mg	$363	In Stock
50 mg	$538	In Stock
100 mg	$779	In Stock
1 mL x 10 mM (in DMSO)	$160	In Stock

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Product Introduction

Bioactivity

Description	Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
In vitro	Angoline as a potent and selective inhibitor of the STAT3 signaling pathway (IC50=11.56 μM).?Angoline inhibited STAT3 phosphorylation and its target gene expression and consequently induced growth inhibition of human cancer cells with constitutively activated STAT3 (IC50=3.14-4.72 μM).?This work provided a novel lead for the development of anti-cancer agents targeting the STAT3 signaling pathway.
Alias	6-Methoxyldihydrochelerythrine

Chemical Properties

Molecular Weight	379.41
Formula	C22H21NO5
Cas No.	21080-31-9

Storage & Solubility Information

Storage

keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/ml (79.07 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6357 mL	13.1784 mL	26.3567 mL	131.7836 mL
5 mM	0.5271 mL	2.6357 mL	5.2713 mL	26.3567 mL
10 mM	0.2636 mL	1.3178 mL	2.6357 mL	13.1784 mL
20 mM	0.1318 mL	0.6589 mL	1.3178 mL	6.5892 mL
50 mM	0.0527 mL	0.2636 mL	0.5271 mL	2.6357 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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