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(Rac)-JBJ-04-125-02

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Purity:95.85%

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COA HNMR HPLC

(Rac)-JBJ-04-125-02

Catalog No. T8872Cas No. 2140807-05-0

(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.

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Pack Size	Price	Availability
1 mg	$107	In Stock
5 mg	$228	In Stock
10 mg	$372	In Stock
25 mg	$629	In Stock
50 mg	$896	In Stock
100 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$276	In Stock

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Product Introduction

Bioactivity

Description	(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.
In vitro	(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M[1].
In vivo	The combination of osimertinib and JBJ-04-125-02 is a significantly more effective treatment approach than either agent alone[1].
Animal Research	Ba/F3, H1975, H3255GR and H3255DR cells were treated with increasing concentrations of inhibitors for 72 hours and growth or the inhibition of growth was assessed by MTS assay according to previously established methods.
Alias	JBJ-04-125-02

Chemical Properties

Molecular Weight	543.61
Formula	C29H26FN5O3S
Cas No.	2140807-05-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (101.17 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8396 mL	9.1978 mL	18.3955 mL	91.9777 mL
5 mM	0.3679 mL	1.8396 mL	3.6791 mL	18.3955 mL
10 mM	0.1840 mL	0.9198 mL	1.8396 mL	9.1978 mL
20 mM	0.0920 mL	0.4599 mL	0.9198 mL	4.5989 mL
50 mM	0.0368 mL	0.1840 mL	0.3679 mL	1.8396 mL
100 mM	0.0184 mL	0.0920 mL	0.1840 mL	0.9198 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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