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NKP608
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Catalog No. TQ0087Cas No. 177707-12-9
Alias NKP-608, NKP 608
NKP608 is a selective and highly effective neurokinin-1 (NK-1) receptor antagonist with anticancer and antianxiety activities, inhibiting the proliferation of human colorectal cancer cells through the Wnt signaling pathway.
NKP608
😃Good
Purity: 99.88%
Catalog No. TQ0087Alias NKP-608, NKP 608Cas No. 177707-12-9
NKP608 is a selective and highly effective neurokinin-1 (NK-1) receptor antagonist with anticancer and antianxiety activities, inhibiting the proliferation of human colorectal cancer cells through the Wnt signaling pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $152 | In Stock | |
| 5 mg | $259 | 5 days | |
| 25 mg | $766 | 8-10 weeks | |
| 50 mg | $995 | 8-10 weeks | |
| 100 mg | $1,580 | 8-10 weeks |
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Purity:99.88%
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Product Introduction
Bioactivity
Chemical Properties
| Description | NKP608 is a selective and highly effective neurokinin-1 (NK-1) receptor antagonist with anticancer and antianxiety activities, inhibiting the proliferation of human colorectal cancer cells through the Wnt signaling pathway. |
| Targets&IC50 | H-SP:2.6 nM (bovine retina), H-SP:27 nM (rat striatum), IP1:2.6 nM, H-SP:13 nM (gerbil midbrain) |
| In vitro | NKP608 inhibited the binding of H-SP to bovine retina with an IC50 of 2.6 nM, and to rat striatum and gerbil midbrain membranes with IC50s of 27 and 13 nM. [5] In human astrocytoma cell (U-373) cultures NKP608 inhibited the SP induced increase in IP1 accumulation with an IC50 of 2.6 nM, indicating potent functional antagonism at the human receptor. [5] |
| In vivo | NKP608 (0.03, 0.1, 0.3, 1 or 3 mg/kg) was given orally 2, 5 or 24 h prior to the i.c.v. administration of 1 mg SPOMe. NKP608 dose-dependently attenuated SPOMe-induced hind foot thumping. [5] |
| Alias | NKP-608, NKP 608 |
| Molecular Weight | 619.99 |
| Formula | C31H24ClF6N3O2 |
| Cas No. | 177707-12-9 |
| Smiles | C([C@H]1N(C(=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)CC[C@H](NC(=O)C=3C4=C(N=CC3)C=CC=C4)C1)C5=CC=C(Cl)C=C5 |
| Relative Density. | 1.44 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: Insoluble. DMSO: 80 mg/mL (129.04 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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