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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $152 | 5 days | |
5 mg | $259 | 5 days | |
25 mg | $766 | 8-10 weeks | |
50 mg | $995 | 8-10 weeks | |
100 mg | $1,580 | 8-10 weeks |
Description | NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo. |
Targets&IC50 | NK1 receptor:2.6 nM |
In vitro | The binding of NKP608 to the bovine retina was characterized by an IC50 of 2.6 nM, whereas the compound's affinity to other receptor binding sites, including NK-2 and NK-3, was much lower. Species differences in IC50 values with NKP608 were less pronounced than with previously described NK-1 receptor antagonists, being 13 and 27 nM in gerbil midbrain and rat striatum, respectively. |
In vivo | Using the hindfoot thumping model in gerbils, NKP608 exhibited a potent NK-1 antagonistic activity following oral administration (ID50: 0.23 mg/kg, 2 h pretreatment), supporting a central activity of NKP608. |
Molecular Weight | 619.98 |
Formula | C31H24ClF6N3O2 |
Cas No. | 177707-12-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: Insoluble DMSO: 100 mg/mL (161.30 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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