neurokinin receptor

Neurokinin Receptor (393-407), rat (SPR393–407), a fragment of the rat neurokinin 1 receptor (NK1R), undergoes rapid endocytosis and subsequent recycling to the plasma membrane upon substance P (SP) binding. This compound is instrumental in researching neurogenic inflammation [1] [2].

Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.

Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.

Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1].

Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex.

gamma-preprotachykinin amide (72-92) acetate is a 21 amino acid peptide belonging to the tachykinin (TK) family and including neurokinin A (NKA) in its C-terminal sequence. gamma-preprotachykinin amide (72-92) acetate possesses higher affinity than NKA for central NK-2 receptors; it shows lower affinity for NK-1 receptors, however, it potently stimulates salivary secretion, which is mediated by NK-1 receptor activation.

Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).

Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R, and mediates its biological effects.

Physalaemin acetate is a non-mammalian tachykinin with high affinity when binding selectively to neurokinin-1 (NK1) receptor.

Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

Tyr0-Neurokinin A, a member of the tachykinin peptide family, acts as an agonist for the Tacr2 receptor. It is utilized in research focused on insulin resistance, obesity, and diabetes [1] [2].

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

Eledoisin Related Peptide (Eledoisin RP) is a tachykinin receptor ligand.

Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .

Biotin-Substance P acts as a neurotransmitter and neuromodulator in the central nervous system. Neurokinin 1 receptor (NK1R) is the endogenous receptor of Biotin-Substance P.

(β-Ala8)-Neurokinin A (4-10), a neuropeptide, acts as a potent and selective agonist for the NK-2 tachykinin receptor [1].

Vapreotide acetate (BMY-41606 acetate) is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).

Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS, targeting the neurokinin 1 receptor (NK1-receptor, NK1R).

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B functions as a competitive antagonist to the Neurokinin B receptor, exhibiting a pA2 value of 5.5. Notably, it does not affect Substance P or Neurokinin A [1].

GR 83074 is a potent and selective antagonist of the NK-2 (Neurokinin Receptor), demonstrating a selectivity factor of 340-fold over NK-1, with a pK B value of 8.23. It does not act as an antagonist for NK-3, affirming its specificity [1].

Substance P (7-11) (Substance P 7-11(TFA)) is a C-terminal fragment of Substance P .

Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).

Hemokinin 1, human TFA acts as a selective full agonist at the tachykinin neurokinin 1 (NK1) receptor, while also being a full agonist at NK2 and NK3 receptors. It is capable of inducing opioid-independent analgesia [1] [2].

Neurokinin A (4-10) TFA is a tachykinin NK 2 receptor agonist [1] .

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), a Neurokinin A analogue, serves as a selective and potent agonist for the NK2 receptor (NK2R). This compound exhibits prokinetic activity, making it a valuable tool for researching smooth muscle contraction across various tissues through NK-2 receptor engagement [1] [2] [3].

Biotin-Neurokinin A, a biotinylated form of Neurokinin A (Substance K), functions as a peptide neurotransmitter within the tachykinin family, primarily engaging the NK-2 receptor. It serves as a significant mediator in the physiological processes of human airway and gastrointestinal tissues [1].

Vapreotide is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).

[MePhe7]-Neurokinin B is a neurokinin NK-3 receptor (NK3R) agonist, exhibiting a potent agonistic activity with an IC50 value of 3 nM. It acts as a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion through the activation of NK3R [1].

[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist that exhibits inhibitory affinities (K_i values) of 1 μM for NK-1, 1.3 μM for NK-2, and approximately 9 μM for NK-3 receptors [1].

Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.

Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter belonging to the tachykinin family, functions through the NK-2 receptor. It serves as a significant mediator in human airway and gastrointestinal tissues [1].

Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.

[Sar9,Met(O2)11]-Substance P (NA) is an agonist of NK1 receptor.

Senktide is an agonist of tachykinin NK3 receptor.

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is an analogue of Substance P that acts on the neurokinin 1 receptor (NK1R) in rat brain, similarly to Substance P but with a significantly extended duration of action. This compound selectively enhances dopamine metabolism within the mesencephalon and midbrain cortex, increases motor activity, and facilitates the resumption of addictive agent-seeking behavior in rats [1] [2] [3].