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Fosnetupitant chloride monohydrochloride
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Catalog No. T78104Cas No. 1643757-72-5
Alias Pronetupitant chloride monohydrochloride
Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1 receptor with a pK i value of 9.5, and a lower affinity for the NK3 receptor with a pK i of 6.1. It serves as a methylene phosphate prodrug of Netupitant [1].
Fosnetupitant chloride monohydrochloride
😃Good
Catalog No. T78104Alias Pronetupitant chloride monohydrochlorideCas No. 1643757-72-5
Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1 receptor with a pK i value of 9.5, and a lower affinity for the NK3 receptor with a pK i of 6.1. It serves as a methylene phosphate prodrug of Netupitant [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1 receptor with a pK i value of 9.5, and a lower affinity for the NK3 receptor with a pK i of 6.1. It serves as a methylene phosphate prodrug of Netupitant [1]. |
| Targets&IC50 | NK1 (human):9.5 (pKi), NK3 (human):6.1 (pKi) |
| In vitro | Fosnetupitant chloride monohydrochloride demonstrates micromolar affinity for 5-HT6 receptors (pKi ∼ 5.2) and L-type Ca2+ channels (pKi > ∼ 5.7), without binding to any other proteins studied [1]. |
| In vivo | Fosnetupitant chloride monohydrochloride (i.v.) quickly metabolizes into Netupitant [1] within minutes. |
| Alias | Pronetupitant chloride monohydrochloride |
| Molecular Weight | 761.52 |
| Formula | C31H37Cl2F6N4O5P |
| Cas No. | 1643757-72-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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