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Maropitant citrate
🥰Excellent
Catalog No. T35344Cas No. 359875-09-5
Maropitant citrate is a synthetic neurokinin-1 receptor antagonist and substance P inhibitor, used for controlling vomiting in cats and dogs.
Maropitant citrate
🥰Excellent
Catalog No. T35344Cas No. 359875-09-5
Maropitant citrate is a synthetic neurokinin-1 receptor antagonist and substance P inhibitor, used for controlling vomiting in cats and dogs.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $53 | In Stock | |
| 5 mg | $118 | In Stock | |
| 10 mg | $173 | In Stock | |
| 25 mg | $289 | In Stock | |
| 50 mg | $429 | In Stock | |
| 100 mg | $638 | In Stock | |
| 200 mg | $889 | In Stock |
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Vofopitant
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Ezlopitant
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Aprepitant
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Rolapitant
SCH619734
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Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
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Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist with analgesic and anti-inflammatory activity.Lanepitant 2HCl inhibits the binding of Substance P to the neurokinin-1 receptor, inhibits neurogenic inflammation and pain transmission, and can be used in the study of painful neuropathic disorders, such as migraines.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Maropitant citrate is a synthetic neurokinin-1 receptor antagonist and substance P inhibitor, used for controlling vomiting in cats and dogs. |
| Targets&IC50 | NK1 receptor: |
| In vitro | Maropitant citrate is a synthetic neurokinin-1 receptor antagonist. [1] |
| In vivo | Maropitant citrate 1 and 2 mg/kg were injected subcutaneously into Rhode Island red hens. Blood samples were collected within 36 hours after administration. The mean maximum plasma concentration, the time to reach the maximum concentration and the elimination half-life were 915.6 ng/ml and 1195.2 ng/ml, 0.49 h and 1.6 h, and 8.47 h and 8.58 h, respectively. [1] Treatment of ulcerative dermatitis (UD) mice with Maropitant citrate (1 mg/kg) significantly reduced the size of UD lesions in mice. [2] |
| Molecular Weight | 678.81 |
| Formula | C38H50N2O9 |
| Cas No. | 359875-09-5 |
| Smiles | C(CC(O)=O)(CC(O)=O)(C(O)=O)O.C([C@H]1[C@@H](NCC2=C(OC)C=CC(C(C)(C)C)=C2)C3CCN1CC3)(C4=CC=CC=C4)C5=CC=CC=C5.O |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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