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Casopitant mesylate
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Casopitant mesylate
Catalog No. T10688Cas No. 414910-30-8
Casopitant mesylate (GW679769B) is a selective, brain-permeable, and orally active antagonist of the neurokinin 1 (NK1) receptor, and it is the second in its class of antiemetics.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,330 | 8-10 weeks | |
| 50 mg | $1,740 | 8-10 weeks | |
| 100 mg | $2,780 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Casopitant mesylate (GW679769B) is a selective, brain-permeable, and orally active antagonist of the neurokinin 1 (NK1) receptor, and it is the second in its class of antiemetics. |
| In vivo | In a ferret model of Cisplatin-induced emesis, Casopitant inhibits retching and vomiting and reduces nausea-like behaviors in a dose-dependent manner. Following a single intraperitoneal dose, radioactive labeled Casopitant ([14C]Casopitant) is rapidly absorbed, with plasma and brain concentrations being approximately equal at two hours post-dosing. [14C]Casopitant is found in the brain as the parent compound and two major oxidative metabolites (M1 and M2), accounting for approximately 76%, 19%, and 3% of the radioactivity, respectively. Casopitant exhibits high affinity for brain NK1 receptors in the ferret [2]. |
| Alias | GW679769B |
| Molecular Weight | 712.72 |
| Formula | C31H39F7N4O5S |
| Cas No. | 414910-30-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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