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SB 218795
Catalog No. T23316Cas No. 174635-53-1
SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.
SB 218795
Catalog No. T23316Cas No. 174635-53-1
SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $44 | In Stock | |
| 2 mg | $61 | In Stock | |
| 5 mg | $97 | In Stock | |
| 10 mg | $172 | In Stock | |
| 25 mg | $347 | In Stock | |
| 50 mg | $562 | In Stock | |
| 100 mg | $793 | In Stock | |
| 500 mg | $1,670 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $117 | In Stock |
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Purity:99.71%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1. |
| Targets&IC50 | NK3 (human):13 nM (Ki), NK2 (human):1220 nM (Ki) |
| In vitro | SB 218795 (3-30 nM) competitively antagonizes senktide-induced contractile responses in a concentration-dependent manner [1]. |
| In vivo | In rabbits, SB 218795 (0.25-1 mg/kg; i.v.) inhibits NK3 receptor-mediated pupillary constriction by maximum inhibition of 78%[1]. |
| Molecular Weight | 396.44 |
| Formula | C25H20N2O3 |
| Cas No. | 174635-53-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 5 mM DMSO: 60 mg/mL (151.35 mM)  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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