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[Sar9,Met(O2)11]-Substance P
🥰Excellent
Catalog No. T7828Cas No. 110880-55-2
Alias NA, Bhsar-sp
[Sar9,Met(O2)11]-Substance P (NA) is an NK1 receptor agonist.
![[Sar9,Met(O2)11]-Substance P](/group3/M00/02/7D/CgoaEGY7NPOEBD7TAAAAANjgZSM909.png)
[Sar9,Met(O2)11]-Substance P
🥰Excellent
Purity: 100%
Catalog No. T7828Alias NA, Bhsar-spCas No. 110880-55-2
[Sar9,Met(O2)11]-Substance P (NA) is an NK1 receptor agonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $77 | In Stock | |
| 5 mg | $287 | In Stock | |
| 10 mg | $517 | In Stock | |
| 25 mg | $843 | In Stock | |
| 50 mg | $1,160 | In Stock | |
| 100 mg | $1,570 | In Stock |
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Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer.
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Maropitant
T7209147116-67-4
Maropitant is a selective neurokinin (NK1) receptor antagonist.
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Befetupitant
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Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization.
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Rolapitant
SCH619734
T3716552292-08-7
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
- $43
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Fosaprepitant dimeglumine
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Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, a water-soluble, N-phosphorylated prodrug of aprepitant with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent selectively binds to human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS), inhibiting receptor binding of endogenous substance P and preventing substance P-induced emesis.
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Ezlopitant
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Netupitant
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Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist with analgesic and anti-inflammatory activity.Lanepitant 2HCl inhibits the binding of Substance P to the neurokinin-1 receptor, inhibits neurogenic inflammation and pain transmission, and can be used in the study of painful neuropathic disorders, such as migraines.
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | [Sar9,Met(O2)11]-Substance P (NA) is an NK1 receptor agonist. |
| Alias | NA, Bhsar-sp |
| Molecular Weight | 1393.66 |
| Formula | C64H100N18O15S |
| Cas No. | 110880-55-2 |
| Smiles | C([C@@H](NC(=O)[C@H]1N(C([C@H](CCCNC(=N)N)N)=O)CCC1)CCCCN)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(N(CC(N[C@H](C(N[C@@H](CCS(C)(=O)=O)C(N)=O)=O)CC(C)C)=O)C)=O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCC2 |
| Relative Density. | 1.43g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (35.88 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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