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Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $52 | In Stock | |
5 mg | $118 | In Stock | |
10 mg | $188 | In Stock | |
25 mg | $400 | In Stock | |
50 mg | $595 | In Stock | |
100 mg | $849 | In Stock | |
1 mL x 10 mM (in DMSO) | $313 | In Stock |
Description | Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. |
In vitro | The process involves the desensitization and resensitization of neuropeptide substance P (SP) through the neurokinin 1 receptor (NK1-R), which may relate to the endocytosis and recycling of NK1-R. Both SP and NK1-R are internalized into clathrin-immunoreactive vesicles and subsequently segregated into distinct compartments. Initially, SP remains intact on the cell surface and in early endosomes but gradually degrades in perinuclear vesicles. SP triggers the clathrin-dependent internalization of NK1-R. Within acidified endosomes, the SP/NK1-R complex disassociates, leading to the degradation of SP while NK1-R is recycled back to the cell surface. This mechanism of SP-induced NK1-R internalization is observed in transfected epithelial cells[1]. |
Alias | Neurokinin P |
Molecular Weight | 1347.63 |
Formula | C63H98N18O13S |
Cas No. | 33507-63-0 |
Smiles | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O |
Relative Density. | 1.42g/cm3 |
Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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