Substance P acetate is a peptide mainly secreted by neurons and is involved in many biological processes including nociception and inflammation. Substance P acetate is a neuroinflammatory factor that can act as a neurotransmitter and neuromodulator in the central nervous system and can be used to study cardiovascular and neurological diseases.

Desensitization and resensitization of Substance P (SP) mediated by the neurokinin 1 receptor (NK1-R) may be related to endocytosis and recycling of NK1-R. SP is intact at the cell surface and in early nuclear endosomes but is slowly degraded in perinuclear vesicles. substance P acetate induces lattice protein-dependent internalization of the NK1-R. SP/ NK1-R complex dissociates in acidified nuclear endosomes, SP is degraded, and NK1-R is recycled to the cell surface.Substance P acetate induces internalization of NK1-R in transfected epithelial cells. [1]