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Fezolinetant
Catalog No. T15278Cas No. 1629229-37-3
Alias ESN-364
Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes.
Fezolinetant
Catalog No. T15278Alias ESN-364Cas No. 1629229-37-3
Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | In Stock | |
| 5 mg | $152 | In Stock | |
| 10 mg | $243 | In Stock | |
| 25 mg | $488 | In Stock | |
| 50 mg | $787 | In Stock | |
| 100 mg | $1,180 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $167 | In Stock |
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Purity:99.70%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes. |
| In vivo | METHODS: Fezolinetant (ESN-364) (1 mg/kg, intravenously) was administered to ovariectomized ewes, and LH/FSH measurements or pharmacokinetic analysis were performed. RESULTS Fezolinetant reversibly inhibited the regular pulsatile secretion of LH in ovariectomized ewes; plasma FSH levels did not change during the experimental period. [1] METHODS: Fezolinetant (5 mg/kg, oral) was administered to castrated cynomolgus monkeys, and LH/FSH measurements or pharmacokinetic analysis were performed. RESULTS Fezolinetant decreased plasma LH, but not FSH, in castrated monkeys. [1] |
| Alias | ESN-364 |
| Molecular Weight | 358.39 |
| Formula | C16H15FN6OS |
| Cas No. | 1629229-37-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (27.9 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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