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Fezolinetant
🥰Excellent
Catalog No. T15278Cas No. 1629229-37-3
Alias ESN-364
Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes.
Fezolinetant
🥰Excellent
Purity: 99.70%
Catalog No. T15278Alias ESN-364Cas No. 1629229-37-3
Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | In Stock | |
| 5 mg | $152 | In Stock | |
| 10 mg | $243 | In Stock | |
| 25 mg | $488 | In Stock | |
| 50 mg | $787 | In Stock | |
| 100 mg | $1,180 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $167 | In Stock |
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Purity:99.70%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes. |
| In vivo | METHODS: Fezolinetant (ESN-364) (1 mg/kg, intravenously) was administered to ovariectomized ewes, and LH/FSH measurements or pharmacokinetic analysis were performed. RESULTS Fezolinetant reversibly inhibited the regular pulsatile secretion of LH in ovariectomized ewes; plasma FSH levels did not change during the experimental period. [1] METHODS: Fezolinetant (5 mg/kg, oral) was administered to castrated cynomolgus monkeys, and LH/FSH measurements or pharmacokinetic analysis were performed. RESULTS Fezolinetant decreased plasma LH, but not FSH, in castrated monkeys. [1] |
| Alias | ESN-364 |
| Molecular Weight | 358.39 |
| Formula | C16H15FN6OS |
| Cas No. | 1629229-37-3 |
| Smiles | C[C@H]1N(CCn2c1nnc2-c1nc(C)ns1)C(=O)c1ccc(F)cc1 |
| Relative Density. | 1.56 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (27.9 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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