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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $73 | In Stock | |
5 mg | $152 | In Stock | |
10 mg | $243 | In Stock | |
25 mg | $488 | In Stock | |
50 mg | $787 | In Stock | |
100 mg | $1,180 | In Stock | |
1 mL x 10 mM (in DMSO) | $167 | In Stock |
Description | Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes. |
In vivo | ESN364 inhibits the pulse pattern of LH in all treated animals. ESN364 (10, 25, 50 mg/kg, orally) also block the LH surge and decreases ovarian hormone levels throughout the menstrual cycle in monkeys. ESN364 (5 mg/kg, p.o.) lowers plasma LH, but not FSH, in the castrated monkey. Fezolinetant (1 mg/kg, iv bolus) reversibly inhibits the regular, pulsatile secretion of LH in the ovariectomized ewe [1]. |
Alias | ESN-364 |
Molecular Weight | 358.39 |
Formula | C16H15FN6OS |
Cas No. | 1629229-37-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 10 mg/mL (27.9 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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