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Men 10376
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Catalog No. T16038Cas No. 135306-85-3
Alias Neurokinin-2 receptor antagonist
Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.
Men 10376
😃Good
Catalog No. T16038Alias Neurokinin-2 receptor antagonistCas No. 135306-85-3
Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $170 | 35 days | |
| 1 mg | $296 | 35 days | |
| 5 mg | $1,170 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor. |
| Targets&IC50 | NK2 receptor (rat small intestine):(ki)4.4 μM |
| In vitro | Men 10376 is a selective tachykinin NK-2 receptor (Ki: 4.4 μM) with no effect on NK-3 receptor (Ki, >10 μM) and low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM) [1]. It exhibits pA2 values of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery), respectively [2]. |
| In vivo | Men 10376 (1 and 3 μmol/kg; in rats) antagonizes the increase in bladder motility induced by the NK-2 receptor agonist [2]. |
| Alias | Neurokinin-2 receptor antagonist |
| Molecular Weight | 1081.22 |
| Formula | C57H68N12O10 |
| Cas No. | 135306-85-3 |
| Relative Density. | 1.361 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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