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Men 10376 TFA(135306-85-3,free)

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Purity:99.22%

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COA HNMR HPLC

Men 10376 TFA(135306-85-3,free)

Catalog No. TP1086

Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.

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Pack Size	Price	Availability
1 mg	$181	In Stock
5 mg	$448	In Stock
10 mg	$659	In Stock
25 mg	$987	In Stock
50 mg	$1,380	In Stock
100 mg	$1,890	In Stock

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Product Introduction

Bioactivity

Description	Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
In vitro	Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
In vivo	Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].
Alias	Men 10376 TFA, Neurokinin-2 receptor antagonist TFA

Chemical Properties

Molecular Weight	1195.25
Formula	C59H69F3N12O12
Cas No.

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 1.43 mg/mL (1.20 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
5 mM	0.1673 mL	0.8366 mL	1.6733 mL	8.3665 mL
10 mM	0.0837 mL	0.4183 mL	0.8366 mL	4.1832 mL
20 mM	0.0418 mL	0.2092 mL	0.4183 mL	2.0916 mL
50 mM	0.0167 mL	0.0837 mL	0.1673 mL	0.8366 mL
100 mM	0.0084 mL	0.0418 mL	0.0837 mL	0.4183 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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