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Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $143 | In Stock | |
5 mg | $412 | In Stock | |
10 mg | $613 | In Stock | |
25 mg | $977 | In Stock | |
50 mg | $1,320 | In Stock | |
100 mg | $1,780 | In Stock |
Description | Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor. |
Targets&IC50 | NK2:ki:560 nM (Human), NK1:Ki: 0.175 nM (Human), |
In vitro | Hemokinin 1 (mouse) (1?nM-3?μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80?mM). Hemokinin 1 (mouse) (10?nM-10?μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB[1]. |
In vivo | Hemokinin 1 (mouse) (0.01-100?nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10?nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2?nmol/kg (0.1-0.4?nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1?nmol/kg (0.07-0.2?nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100?nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1]. |
Molecular Weight | 1473.72 |
Formula | C63H104N22O17S |
Smiles | C[C@@H](O)[C@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCC/N=C(N)/N)=O)CO)=O)CCC/N=C(N)\N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(C)C)=O)=O)CC1=CC=C(O)C=C1)=O)CC2=CC=CC=C2)=O)CCC(N)=O)=O)CCC/N=C(N)\N)=O.CC(O)=O |
Relative Density. | no data available |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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