Shopping Cart
- Remove All
Your shopping cart is currently empty
[Lys5,MeLeu9,Nle10]-NKA(4-10)
🥰Excellent
Catalog No. TP1883Cas No. 137565-28-7
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
![[Lys5,MeLeu9,Nle10]-NKA(4-10)](/group3/M00/03/40/CgoaEWY7RfeEGRVZAAAAAIQ7qKg465.png)
[Lys5,MeLeu9,Nle10]-NKA(4-10)
🥰Excellent
Purity: 100%
Catalog No. TP1883Cas No. 137565-28-7
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $103 | In Stock | |
| 5 mg | $257 | In Stock | |
| 10 mg | $380 | In Stock | |
| 25 mg | $592 | In Stock | |
| 50 mg | $816 | In Stock | |
| 100 mg | $1,090 | In Stock | |
| 200 mg | $1,480 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "[Lys5,MeLeu9,Nle10]-NKA(4-10)"
Aprepitant
MK-869, MK-0869, L-754030, Aprepitant`
T1743170729-80-3
Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer.
- $48
Size
QTY
Maropitant
T7209147116-67-4
Maropitant is a selective neurokinin (NK1) receptor antagonist.
- $43
Size
QTY
Befetupitant
Ro67-5930
T14524290296-68-3In house
Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization.
- $490
Size
QTY
Rolapitant
SCH619734
T3716552292-08-7
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
- $43
Size
QTY
Fosaprepitant dimeglumine
MK-0517, L785298, Fosaprepitant dimeglumine salt
T1790265121-04-8
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, a water-soluble, N-phosphorylated prodrug of aprepitant with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent selectively binds to human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS), inhibiting receptor binding of endogenous substance P and preventing substance P-induced emesis.
- $45
Size
QTY
N-Acetyl-L-tryptophan
N-acetyltryptophan
T87891218-34-4
N-Acetyl-L-tryptophan (N-acetyltryptophan) is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).
- $30
Size
QTY
Ezlopitant
CJ-11974, CJ11974, CJ 11974
T68068147116-64-1In house
Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain.
- $85
Size
QTY
(R)-CJ 11974
T68068L187281-35-2In house
(R)-CJ 11974: non-peptide NK1 receptor antagonist, may relieve pain and prevent chemo-induced vomiting.
- $195
Size
QTY
Netupitant
Ro 67-31898/000, CID 6451149
T6905290297-26-6
Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
- $47
Size
QTY
Vofopitant
GR 205171
T13329168266-90-8In house
Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).
- $100
Size
QTY
Vofopitant dihydrochloride
Vofopitant 2HCl, GR 205171A
T13329L168266-51-1In house
Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively. It is a potential compound for the treatment of pathological vomiting.
- $100
Size
QTY
Lanepitant 2HCl
LY-303870 dihydrochloride, LY303870 dihydrochloride, LY 303870 dihydrochloride, Lanepitant dihydrochloride
T25616170508-05-1In house
Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist with analgesic and anti-inflammatory activity.Lanepitant 2HCl inhibits the binding of Substance P to the neurokinin-1 receptor, inhibits neurogenic inflammation and pain transmission, and can be used in the study of painful neuropathic disorders, such as migraines.
- $195
Size
QTY
Select Batch
Purity:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively). |
| Molecular Weight | 803.99 |
| Formula | C39H65N9O9 |
| Cas No. | 137565-28-7 |
| Smiles | [C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCCN)=O)C(N[C@H](C(NCC(N([C@H](C(N[C@@H](CCCC)C(N)=O)=O)CC(C)C)C)=O)=O)C(C)C)=O |
| Relative Density. | 1.193 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O: 1 mg/mL |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy [Lys5,MeLeu9,Nle10]-NKA(4-10) | purchase [Lys5,MeLeu9,Nle10]-NKA(4-10) | [Lys5,MeLeu9,Nle10]-NKA(4-10) cost | order [Lys5,MeLeu9,Nle10]-NKA(4-10) | [Lys5,MeLeu9,Nle10]-NKA(4-10) chemical structure | [Lys5,MeLeu9,Nle10]-NKA(4-10) formula | [Lys5,MeLeu9,Nle10]-NKA(4-10) molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.