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CS-003 Free base
Catalog No. T10892Cas No. 191672-52-3
CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on neurokinin-related respiratory diseases.
CS-003 Free base
Catalog No. T10892Cas No. 191672-52-3
CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on neurokinin-related respiratory diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,570 | 10-14 weeks | |
| 50 mg | $3,380 | 10-14 weeks | |
| 100 mg | $4,600 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on |
| Targets&IC50 | NK2:0.54 nM (ki), NK1:2.3 nM (ki), NK3:0.74 nM (ki) |
| In vitro | CS-003 (0.01-10 μM; 24 hours) inhibits inositol phosphate formation induced by NK1, NK2, or NK3 in a concentration-dependent manner, with pA2 values of 8.7, 9.4, and 9.5 μM, respectively. |
| In vivo | CS-003 (intravenous injection; 0.01-3.0 mg/kg; neurokinin A/B/C 5 minutes before injection) inhibits substance P-induced increases in tracheal vascular permeability and neurokinin A and B-induced bronchial contraction, with ID50 values of 0.13, 0.040, and 0.063 mg/kg, respectively. |
| Molecular Weight | 673.65 |
| Formula | C34H38Cl2N2O6S |
| Cas No. | 191672-52-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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