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Tradipitant
🥰Excellent
Catalog No. T17156Cas No. 622370-35-8
Alias VLY-686, LY686017
Tradipitant (VLY-686) is an antagonist of neurokinin-1.
Tradipitant
🥰Excellent
Purity: 99.42%
Catalog No. T17156Alias VLY-686, LY686017Cas No. 622370-35-8
Tradipitant (VLY-686) is an antagonist of neurokinin-1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $55 | In Stock | |
| 2 mg | $77 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $347 | In Stock | |
| 50 mg | $516 | In Stock | |
| 100 mg | $736 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $159 | In Stock |
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Purity:99.42%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tradipitant (VLY-686) is an antagonist of neurokinin-1. |
| In vitro | Tradipitant binds to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral), and the medial amygdaloid nucleus [1]. |
| In vivo | Tradipitant (intravenously administered) treatment localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands [1]. |
| Alias | VLY-686, LY686017 |
| Molecular Weight | 587.9 |
| Formula | C28H16ClF6N5O |
| Cas No. | 622370-35-8 |
| Smiles | FC(F)(F)c1cc(Cn2nnc(c2-c2ccncc2)-c2ncccc2C(=O)c2ccccc2Cl)cc(c1)C(F)(F)F |
| Relative Density. | 1.45 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (102.06 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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